S3 offers "4 nines" of availability, or 99.99%.
For backups, you would be looking for Durability (chance that a stored object is lost). On that account, S3 offers "11 9's", or 99.9999999%
Here's a blurb from the S3 FAQ:
Data Durability and Reliability
Amazon S3 provides a highly durable storage infrastructure designed
for mission-critical and primary data storage. Objects are redundantly
stored on multiple devices across multiple facilities in an Amazon S3
Region. To help ensure durability, Amazon S3 PUT and COPY operations
synchronously store your data across multiple facilities before
returning SUCCESS. Once stored, Amazon S3 maintains the durability of
your objects by quickly detecting and repairing any lost redundancy.
Amazon S3 also regularly verifies the integrity of data stored using
checksums. If corruption is detected, it is repaired using redundant
data. In addition, Amazon S3 calculates checksums on all network
traffic to detect corruption of data packets when storing or
retrieving data.
Amazon S3’s standard storage is:
- Backed with the Amazon S3 Service Level Agreement.
- Designed to provide 99.999999999% durability and 99.99% availability of objects over a given year.
- Designed to sustain the concurrent loss of data in two facilities.
As for the Regions, you would have to implement a DIY replication strategy if you truly wanted cross-region failover. An no, an entire region has not failed yet, but I guess there's a first for everything.
Here's some more info on the topic:
Q: How durable is Amazon S3?
Amazon S3 is designed to provide
99.999999999% durability of objects over a given year. This durability level corresponds to an average annual expected loss of 0.000000001%
of objects. For example, if you store 10,000 objects with Amazon S3,
you can on average expect to incur a loss of a single object once
every 10,000,000 years. In addition, Amazon S3 is designed to sustain
the concurrent loss of data in two facilities.
Q: How is Amazon S3 designed to achieve 99.999999999% durability?
Amazon S3 redundantly stores your objects on multiple devices across
multiple facilities in an Amazon S3 Region. The service is designed to
sustain concurrent device failures by quickly detecting and repairing
any lost redundancy. When processing a request to store data, the
service will redundantly store your object across multiple facilities
before returning SUCCESS. Amazon S3 also regularly verifies the
integrity of your data using checksums.