fs.writeFile, just like all the other methods in the fs
module are implemented as simple wrappers around standard POSIX functions (as stated in the docs).
Digging a bit in nodejs' code, one can see that the fs.js, where all the wrappers are defined, uses fs.c for all its file system calls. More specifically, the write
method is used to write the contents of the buffer. It turns out that the POSIX specification for write explicitly says that:
Atomic/non-atomic: A write is atomic if the whole amount written in
one operation is not interleaved with data from any other process.
This is useful when there are multiple writers sending data to a
single reader. Applications need to know how large a write request can
be expected to be performed atomically. This maximum is called
{PIPE_BUF}. This volume of IEEE Std 1003.1-2001 does not say whether
write requests for more than {PIPE_BUF} bytes are atomic, but requires
that writes of {PIPE_BUF} or fewer bytes shall be atomic.
So it seems it is pretty safe to write, as long as the size of the buffer is smaller than PIPE_BUF. This is a constant that is system-dependent though, so you might need to check it somewhere else.