I just got it to compile, though I cannot import the "R" class, for now.
Execute these steps:
First, install the Xtend SDK in the Eclipse update manager, by entering "http://download.eclipse.org/modeling/tmf/xtext/updates/composite/releases/", expanding node "TMF Xtext-2.1.0", and selecting "Xtend2 SDK". Wait, then restart Eclipse.
In your Eclipse Android project folder, edit file ".project" (e.g. by typing "nano .project" in Terminal on OSX), and change it so that it resembles this (except for the name; you can actually copy the whole content over and change the name back to your project name):
<?xml version="1.0" encoding="UTF-8"?>
<projectDescription>
<name>TestAndroidXtend</name>
<comment></comment>
<projects>
</projects>
<buildSpec>
<buildCommand>
<name>com.android.ide.eclipse.adt.ResourceManagerBuilder</name>
<arguments>
</arguments>
</buildCommand>
<buildCommand>
<name>com.android.ide.eclipse.adt.PreCompilerBuilder</name>
<arguments>
</arguments>
</buildCommand>
<buildCommand>
<name>org.eclipse.jdt.core.javabuilder</name>
<arguments>
</arguments>
</buildCommand>
<buildCommand>
<name>org.eclipse.xtext.ui.shared.xtextBuilder</name>
<arguments>
</arguments>
</buildCommand>
<buildCommand>
<name>com.android.ide.eclipse.adt.ApkBuilder</name>
<arguments>
</arguments>
</buildCommand>
</buildSpec>
<natures>
<nature>com.android.ide.eclipse.adt.AndroidNature</nature>
<nature>org.eclipse.jdt.core.javanature</nature>
<nature>org.eclipse.xtext.ui.shared.xtextNature</nature>
</natures>
Then insert the following into file ".classpath", within the classpath element:
<classpathentry kind="con" path="org.eclipse.pde.core.requiredPlugins"/>
I put it before the entry with com.android.ide.eclipse.adt.ANDROID_FRAMEWORK, perhaps you should do that too.
Back in Eclipse, refresh the project with F5, then create a folder "META-INF" at the toplevel of the project, and create an empty file "MANIFEST.MF". Paste into it these contents:
Manifest-Version: 1.0
Bundle-ManifestVersion: 2
Bundle-Name: Xtend Tutorial
Bundle-SymbolicName: xtend.tutorial
Bundle-Version: 2.1.0.qualifier
Bundle-Vendor: Eclipse Modeling
Bundle-RequiredExecutionEnvironment: J2SE-1.5
Require-Bundle: org.eclipse.xtext.xtend2.lib;bundle-version="2.0.0",
org.junit4,
org.aopalliance;bundle-version="1.0.0"
Perform a "Project" -> "Clean" on your project, and you can now create and use Xtend classes.
As mentioned before, I cannot import the R class, perhaps Xtend just looks in the normal "src" folder for class files.