Short answer: no.
However, I am not aware of any situation in which the conservative approach of the compiler will change the number of reads or writes if you follow this approach:
When reading a cross-thread visible location, save its value to a local before doing any further manipulation; similarly, restrict writes to a single assignment.
The Delphi compiler does not perform common subexpression elimination (CSE) on non-local location expressions when there are calls to non-inlined methods between the expressions, as the compiler doesn't do interprocedural optimization and thus it would not be correct even for single-threaded code.
So, you may want to use InterlockedExchange() to do your reads and writes to force this; additionally, this will cause a full memory barrier, so the processor won't reorder reads and writes either.
volatile
means is imprecise at best. – Persevere