Mmm, might be as well the "apache dummy connections". Check you access logs for "internal dummy connection", theses are used by the master apache process to send orders to his child processes (like suicide yourself, or we need to reload conf). And theses connections are made in HTTP/1.0 without HOST set.
http://wiki.apache.org/httpd/InternalDummyConnection
Theses #$!"#sh#f#ck*$! connections are making a lot of bugs around there, (cache things, no HTTP/1.1, etc). One 'simple' solution is not having your hostname based Virtuahost serving you main application as the default virtualhost. Keep a very simple default virtualhost with the 'it works' page, or something very simple "if you get this page you might try to get a browser with HTTP/1.1 support somewhere", as a static page. Then all HTTP/1.0 traffic or people accessing your server by IP only, will not be in your real application.
To be complete I've seen a company this year with bad proxies removing the Host header from all their outgoing HTTP traffic. But theses bad guys are dumbs, I don't think there's a lot of people still browsing in HTTP/1.0 without hosts.
Host: ...
header. So, it could happen that a normal user access your website without theHost: ...
header, but it is really unlikely. – Volny