Performance is a big hairy problem. Make sure you are optimizing for the right thing.
Free advice is always worth its price, and there is no substitute for actual experimentation.
The purpose of an index is to find matching rows and help retrieve the data when found.
A non-clustered index on your search criteria will help to find rows, but there needs to be additional operation to get at the row's data.
If there is no clustered index, SQL uses an internal rowId to point to the location of the data.
However, if there is a clustered index on the table, that rowId is replaced by the data values in the clustered index.
So the step of reading the rows data would not be needed, and would be covered by the values in the index.
Even if a clustered index isn't very good at being selective, if those keys are frequently most or all of the results requested - it may be helpful to have them as the leaf of the non-clustered index.