TL;DR: Go to the Sources tab and delete all breakpoints for the site.
I had a similar problem. My site was very slow to load, but only in specific circumstances:
- Dev-tools were open.
- Tab was in a normal window. (not incognito mode)
- Profiling was not enabled.
If (and only if) all three of those conditions were met, the site would load unbearably slowly (15+ seconds; normally ~3s), plus have performance issues for certain operations on the site (like changing which subpanel was open). It was very strange.
Like you, I tried disabling all of my extensions, yet the problem persisted.
Attempt 1: I tried clearing all of the site's cookies and local-storage, using the info/lock dropdown at the left of the address-bar. Suprisingly, that seems to have fixed it! (edit: this was not the root problem; see below for that)
So the problem must be that my site was storing too much data in local storage or something, such that dev-tools was choking on it (but only in specific cases, for some reason). This also matches with the issue resolving in incognito mode: incognito mode uses a "clear slate" for site cookies/local-storage.
Anyway, it's an odd one, but the cookies/local-storage clearing seems to have worked for my case. (If the issue comes up again, and the solution above doesn't fix it, I'll try to remember to mention it.)
Update: Oddly, having the profiler on still speeds things up even after the fix (ie. those three conditions being met still slows down page loading and actions, just much less than before the fix). So apparently the fix merely "reduces the intensity" of the problem rather than fully fixing it; like, by resetting local-storage, it lessens the size of that data, which somehow is a variable affecting the core problem (not yet identified).
Attempt 2: I believe I have found the root problem and solution: I removed all breakpoints for the site, and the slowdown was solved completely. So the problem seems to be that I had lots of unneeded breakpoints set at various places in my website code (some enabled, some disabled). Some of these must have been placed in/near "hotspots" that were getting called frequently. By having the dev-tools open, the Javascript engine must have had to start performing some processing related to the breakpoints, slowing things down.
My guess is that the problem would also be fixed by disabling the "JavaScript source maps" settings (as that's the only thing I can think would cause so much slowdown), but I haven't confirmed this.
Version 80.0.3987.87
and my react apps works really well. Did you try another browser? What browser did you try? Before concluding that chrome was the issue did you try chrome on another computer? – Abolition