"The best way," of course, is subjective but, to me, the best way to do aspect-oriented programming in .NET is by using well known design techniques. For instance, by applying the SOLID principles you can achieve the flexibility and modularity you need to allow adding cross-cutting concerns. If you have the design right, you will even be able to apply most cross-cutting concerns without any framework. It is a fallacy to think that OOP is unsuited for doing AOP.
Here are some pointers:
- Don't depend on concrete instances, but depend on abstractions.
- Don't mix cross-cutting concerns and business logic in the same class.
- Adding cross-cutting concerns by wrapping classes with business logic in classes that implement those concerns (decorators).
- Find common artifacts in your design and model them equally, preferably using the same type of abstractions. Take a look at this and this for instance.
When you've got the right abstractions in place, adding new cross-cutting concerns to the system is just a matter of writing a new decorator class and wrapping it around the right implementations. If abstractions are generic, you can wrap a single decorator around a large group of classes (which is exactly what AOP is about).
Although techniques such as dynamic proxies and code weaving could make it easier to work with a badly designed application, there is truly no alternative for good design. Sooner or later you will get burned. This doesn't mean that dynamic proxy generation and code weaving should not be used though. But without a proper application design even those techniques will just be marginally helpful.