Using Resources in XAML is the way to go. Although there are many great answers to this question, I would like to add my two cents to the SCOPE of the Resource.
For Global accessibility in all of the Windows and User Controls of the Project, you can have your resource in the App.xaml file
<Application.Resources>
<Style TargetType="{x:Type Control}" x:Key="GlobalFontSize">
<Setter Property="FontSize" Value="28"/>
</Style>
</Application.Resources>
For accessibility at a Window level, you can have your resource in your xaml file for Window
<Window.Resources>
<Style TargetType="{x:Type Control}" x:Key="GlobalFontSize">
<Setter Property="FontSize" Value="28"/>
</Style>
</Window.Resources>
You could even have it at a Control level, for example
<DockPanel.Resources>
<Style TargetType="{x:Type Control}" x:Key="GlobalFontSize">
<Setter Property="FontSize" Value="28"/>
</Style>
</DockPanel.Resources>