Build a lookup trie of just the sorted-anagram of each word of the dictionary. This is a one time cost.
By sorted anagram I mean: if the word is eat
you represent it as aet
. It the word is tea
, you represent it as aet
, bubble
is represent as bbbelu
etc
Since this is scrabble, assuming you have 8 tiles (say you want to use one from the board), you will need to maximum check 2^8 possibilities.
For any subset of the tiles from the set of 8, you sort the tiles, and lookup in the anagram trie.
There are at most 2^8 such subsets, and this could potentially be optimized (in case of repeating tiles) by doing a more clever subset generation.
If this is a more general problem, where 2^{number of tiles} could be much higher than the total number of anagram-words in the dictionary, it might be better to use frequency counts as in Ivaylo's answer, and the lookups potentially can be optimized using multi-dimensional range queries. (In this case 26 dimensions!)
Sorry, this might not help you as-is (I presume you are trying to do some exercise and have constraints), but I hope this will help the future readers who don't have those constraints.