This has to do with matplotlib, not Spyder. Placing the location of a figure explicitly appears to be one of those things for which there's really just workarounds ... see the answers to the question here. That's an old question, but I'm not sure there's been change since then (any matplotlib devs, feel free to correct me!).
The second monitor shouldn't make any difference, it sounds like the issue is just that the figure is being replaced with a new one.
Fortunately you can update figures you've moved to where you want them pretty easily, by using the object interface specifically, and updating the Axes object without creating a new figure. An example is below:
import matplotlib.pyplot as plt
import numpy as np
# Create the figure and axes, keeping the object references
fig = plt.figure()
ax = fig.add_subplot(111)
p, = ax.plot(np.linspace(0,1))
# First display
plt.show()
# Some time to let you look at the result and move/resize the figure
plt.pause(3)
# Replace the contents of the Axes without making a new window
ax.cla()
p, = ax.plot(2*np.linspace(0,1)**2)
# Since the figure is shown already, use draw() to update the display
plt.draw()
plt.pause(3)
# Or you can get really fancy and simply replace the data in the plot
p.set_data(np.linspace(-1,1), 10*np.linspace(-1,1)**3)
ax.set_xlim(-1,1)
ax.set_ylim(-1,1)
plt.draw()