I think part of what you're looking for is found in the Shell layer, this will let you do anything you'd ordinarily do in a terminal emulator, you could launch iPython or the like from here.
Once the layer is installed you can use the following key bindings:
|-------------+------------------------------------------------------|
| Key binding | Description |
|-------------+------------------------------------------------------|
| SPC ' | Open, close or go to the default shell |
| SPC " | Open external terminal emulator in current directory |
| SPC p ' | Open a shell in the project's root |
| SPC p " | Open external terminal emulator in project root |
| TAB | browse completion with `helm` |
| SPC m H | browse history with helm (works in eshell and shell) |
| C-j | next item in history |
| C-k | previous item in history |
|-------------+------------------------------------------------------|
The other part is in the Python layer which supports spawning a python interpreter, this can by launched by SPC m s i
.
If you like Jupyter Notebook (formerly iPython notebook) there's a layer for that too (ipython-notebook), once installed you can launch it with SPC a i n
.