I've built my app so far using node-mysql. I just set up a securely accessible mysql database using AWS RDS service and have tested an SSL connection successfully with the mysql command line client. I have Amazon's public key .pem file. node-mysql doesn't seem to have an api for the SSL connect option.
The only one I've found so far is Node-mysql-libmysqlclient but I got errors trying to connect with it, something about a bindings dependency being null so I'm not sure if I should trust it. Suggestions of which module/api to use? Alternatively, if you know what I need to modify in node-mysql I'd be willing to tinker a bit but it looks like it's using lower level Sockets to connect to MySQL so I'm not sure how hard it would be to get the SSL part added on.