Having the database on a local machine reduces the problem; however, most applications and databases will be on different machines, where each round trip takes at least a couple of milliseconds.
A database will also need a lot of locking and latching checks for each individual query. Context switches have already been mentioned by meriton. If you don't use a surrounding transaction, it also has to build implicit transactions for each query. Some query parsing overhead is still there, even with a parameterized, prepared query or one remembered by string equality (with parameters).
If the database gets filled up, query times may increase, compared to an almost empty database in the beginning.
If your database is to be used by other application, you will likely hammer it: even if your application works, others may slow down or even get an increasing number of failures, such as timeouts and deadlocks.
Also, consider having more than two levels of data. Imagine three levels: Blogs, Entries, Comments, with 100 blogs, each with 10 entries and 10 comments on each entry (for average). That's a SELECT 1+N+(NxM) situation. It will require 100 queries to retrieve the blog entries, and another 1000 to get all comments. Some more complex data, and you'll run into the 10000s or even 100000s.
Of course, bad programming may work in some cases and to some extent. If the database will always be on the same machine, nobody else uses it and the number of cars is never much more than 100, even a very sub-optimal program might be sufficient. But beware of the day any of these preconditions changes: refactoring the whole thing will take you much more time than doing it correctly in the beginning. And likely, you'll try some other workarounds first: a few more IF clauses, memory cache and the like, which help in the beginning, but mess up your code even more. In the end, you may be stuck in a "never touch a running system" position, where the system performance is becoming less and less acceptable, but refactoring is too risky and far more complex than changing correct code.
Also, a good ORM offers you ways around N+1: (N)Hibernate, for example, allows you to specify a batch-size (merging many SELECT * FROM Wheels WHERE CarId=?
queries into one SELECT * FROM Wheels WHERE CarId IN (?, ?, ..., ?)
) or use a subselect (like: SELECT * FROM Wheels WHERE CarId IN (SELECT Id FROM Cars)
).
The most simple option to avoid N+1 is a join, with the disadvantage that each car row is multiplied by the number of wheels, and multiple child/grandchild items likely ending up in a huge cartesian product of join results.