I am aware that this is an old question (being from 2012) however the answer has changed and there is now a tool that can do this. Jim Thunderbirds PHP-to-C Extension toolset provides the means to take a simple class in one file all the way up to a complicated multi file multi-level namespaced framework and convert it to a C-extension that can then be installed into your PHP server.
While in many use cases doing so is not needed as the ordinary PHP code will work just as good in some cases significant performance improvements can be experienced. The information page shows that an ordinary class (deliberately designed to take a long time) took 16.802139997482 seconds as plain vanilla PHP, and 3.9628620147705 as a PHP extension built using the tool.
As an added advantage the tool also provides an additional feature. The ability to combine PHP code (to be converted to C) and native C code within the same extension which can produce even greater performance enhancements. The same example used above only tool 0.14397192001343 seconds when much of the intensive code was moved to a bubble sort C code and simply calling it from within the PHP code.
As a side note functionally to the end developers using the code using the extension is very much similar to having the files manually included in the PHP file being developed except it doesn't have to be specifically included as it is done through the PHP extensions component.
(Disclaimer: I am not affiliated with this developer but am glad to have come across it as it is thus far working for converting some of my intensive classes into PHP extensions without needing to know C).