We have a number of internal image formats which I process in Matlab. I have read/write functions for all of them. For specificity, consider the TGA image format, for which there is a file exchange image reader.
Matlab has reasonable drag and drop support for image formats supported by imread.
That is, you can drag an image from explorer, drop it on the "Workspace" pane, and Matlab will read in the image, and copy it into your workspace.
I'd like to be able to add drag and drop support, and imread support for TGA files. (imread has nice autocomplete for filenames for instance, tga_read_image does not.)