I was just about to start using VS2015 with an existing WPF project including MVVM Light toolkit but found that there is a problem with this regarding the WPF/Xaml designer.
The project includes a few EventToCommand tags in markup like this:
<i:Interaction.Triggers>
<i:EventTrigger EventName="Loaded">
<command:EventToCommand Command="{Binding LoadedCommand}"></command:EventToCommand>
</i:EventTrigger>
</i:Interaction.Triggers>
When loading xaml files using the EventToCommand construct the designer fails to load the file and reports "Invalid markup". The error list then shows:
The type 'EventToCommand' from assembly 'GalaSoft.MvvmLight.Platform' is built with an older version of the Blend SDK, and is not supported in a Windows Presentation Framework 4 project.
The project is set to target .NET 4.5 and it works perfectly well i VS2013 without any changes at all. All this looks very similar to the question Where do I find Galasoft.MvvmLight.WPF45 assembly? but the suggested solution there does not help at all in VS2015.
I have tested this in a new project created from MVVM Light template but I get the same error with that new project too. The MVVM Light version is MvvmLightLibs 5.2.0 from NuGet, I have also tested with older v4.x version of MvvmLightLibs.