How about a lightweight wrapper around tkinter so that it doesn't require a lot of setup? PySimpleGUI is built on top of tkinter which means it runs everywhere tkinter runs.
The advantage over using it versus tkinter is the amount of code that is required. The PySimpleGUI programs tend to be really compact.
Here is an example showing a custom layout using many of the available widgets.
The code to generate it is at the end. It may look like a lot of code, but that's it. It would take pages and pages and pages of tkinter code to do the same thing.
import PySimpleGUI as sg
sg.ChangeLookAndFeel('GreenTan')
# ------ Menu Definition ------ #
menu_def = [['&File', ['&Open', '&Save', 'E&xit', 'Properties']],
['&Edit', ['Paste', ['Special', 'Normal', ], 'Undo'], ],
['&Help', '&About...'], ]
# ------ Column Definition ------ #
column1 = [[sg.Text('Column 1', background_color='lightblue', justification='center', size=(10, 1))],
[sg.Spin(values=('Spin Box 1', '2', '3'), initial_value='Spin Box 1')],
[sg.Spin(values=('Spin Box 1', '2', '3'), initial_value='Spin Box 2')],
[sg.Spin(values=('Spin Box 1', '2', '3'), initial_value='Spin Box 3')]]
layout = [
[sg.Menu(menu_def, tearoff=True)],
[sg.Text('(Almost) All widgets in one Window!', size=(30, 1), justification='center', font=("Helvetica", 25), relief=sg.RELIEF_RIDGE)],
[sg.Text('Here is some text.... and a place to enter text')],
[sg.InputText('This is my text')],
[sg.Frame(layout=[
[sg.Checkbox('Checkbox', size=(10,1)), sg.Checkbox('My second checkbox!', default=True)],
[sg.Radio('My first Radio! ', "RADIO1", default=True, size=(10,1)), sg.Radio('My second Radio!', "RADIO1")]], title='Options',title_color='red', relief=sg.RELIEF_SUNKEN, tooltip='Use these to set flags')],
[sg.Multiline(default_text='This is the default Text should you decide not to type anything', size=(35, 3)),
sg.Multiline(default_text='A second multi-line', size=(35, 3))],
[sg.InputCombo(('Combobox 1', 'Combobox 2'), size=(20, 1)),
sg.Slider(range=(1, 100), orientation='h', size=(34, 20), default_value=85)],
[sg.InputOptionMenu(('Menu Option 1', 'Menu Option 2', 'Menu Option 3'))],
[sg.Listbox(values=('Listbox 1', 'Listbox 2', 'Listbox 3'), size=(30, 3)),
sg.Frame('Labelled Group',[[
sg.Slider(range=(1, 100), orientation='v', size=(5, 20), default_value=25),
sg.Slider(range=(1, 100), orientation='v', size=(5, 20), default_value=75),
sg.Slider(range=(1, 100), orientation='v', size=(5, 20), default_value=10),
sg.Column(column1, background_color='lightblue')]])],
[sg.Text('_' * 80)],
[sg.Text('Choose A Folder', size=(35, 1))],
[sg.Text('Your Folder', size=(15, 1), auto_size_text=False, justification='right'),
sg.InputText('Default Folder'), sg.FolderBrowse()],
[sg.Submit(tooltip='Click to submit this form'), sg.Cancel()]]
window = sg.Window('Everything bagel', default_element_size=(40, 1), grab_anywhere=False).Layout(layout)
button, values = window.Read()