As fast as I know from the flash version:
- its build/designed and optimized for speed, jquery is build for consistent workflow.
- Its using object pooling, aka recycling of multiple types of internal objects to minimize instantiation
- its using optimized loops for every scenario
- its using info objects to help/ state what properties are animating.
- im not sure if they use the same easing functions, but that could make difference too.
Tweenlite has a long history as tweenengine, it also has many features that are not included in jQuery.