With a powerful gradle build system in android studio you can do it without even touching your code. You can also make your debug build with debuggable false to test what differences are
buildTypes {
debug {
runProguard false/true
proguardFile getDefaultProguardFile('proguard-android.txt')
debuggable false/true
}
release {
runProguard true/false
proguardFile getDefaultProguardFile('proguard-android.txt')
debuggable false/true
}
}
Power of Gradle.
Note : You wont be able to see the process in the left pane of DDMS under device info even the application running in device, if it has debuggable false in build configuration.