Same Answer Plus Opinion
As other answers have already stated, Enlive will let you use pure HTML templates, while Hiccup leverages Clojure data structures to generate HTML.
But, as I think we'd all agree, HTML should be semantic and describe the structure of the page, while layout and look-and-feel should be left to CSS and JavaScript. At least out of my experience, front-end designers should not be responsible for drastically altering the structure of a page, but rather responsible for styling and placement through CSS and JavaScript.
Whenever working on an application more complex than a collection of static HTML pages, if a front-end designer feels the need to change a page's structure, that should be a joint conversation with the developer who put it together. With this in mind, the developer should choose a templating scheme or HTML generation method that allows him/her to be most productive. My two cents.