Web2py looks like a very nice Python framework but I am wondering if it is suitable to use for a large public web site. What sorts of issues might I run into? I'm not worried about technical scalability so much as UI/UX limitations, ability to connect other components, etc.
web2py is a very capable web server application framework. UI/UX (User interface / Experience) limitations does not arises usually from a server framework.
There are quite a number of free application that demonstrates it's capabilities:
If you want to compare it with other server frameworks, there are quite a few documents out there that you can read on.
The following discussion should add to information here
You have to be more specific to make a judgement or evaluate a server framework than what you have mentioned.
[Edit: based on comments]
While the examples in the link provided by mdipierro may not inspire confidence with regard to desired UI/UX solutions. It would be premature to consider that because of web2py or any other server framework. It might point to the fact that all these are implemented by a resource constrained team.
You might take a look at this list of sites powered by web2py.
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