Using .NET Framework 4.7 and Windows 10 Creators Update (1703) or newer you must do the following things to configure high DPI support for your Windows Form application:
Declare compatibility with Windows 10.
To do this, add the following to your manifest
file:
<compatibility xmlns="urn:schemas-microsoft.com:compatibility.v1">
<application>
<!-- Windows 10 compatibility -->
<supportedOS Id="{8e0f7a12-bfb3-4fe8-b9a5-48fd50a15a9a}" />
</application>
</compatibility>
Enable per-monitor DPI awareness in the app.config
file.
Windows Forms introduces a new System.Windows.Forms.ApplicationConfigurationSection element to support new features and customizations added starting with the .NET Framework 4.7. To take advantage of the new features that support high DPI, add the following to your application configuration file.
<System.Windows.Forms.ApplicationConfigurationSection>
<add key="DpiAwareness" value="PerMonitorV2" />
</System.Windows.Forms.ApplicationConfigurationSection>
Important
In previous versions of the .NET Framework, you used the manifest to add high DPI support. This approach is no longer recommended, since it overrides settings defined on the app.config file.
Call the static EnableVisualStyles method.
This should be the first method call in your application entry point. For example:
static void Main()
{
Application.EnableVisualStyles();
Application.SetCompatibleTextRenderingDefault(false);
Application.Run(new Form1());
}
The advantage of this is the support for dynamic DPI scenarios in which the user changes the DPI or scale factor after a Windows Forms application has been launched.
Source: High DPI support in Windows Forms