Pharo if your focus is web development only.
Squeak if you want more stuff to play with and don't care if you're a bit behind with the latest web development stuff using Seaside and don't mind if there are libraries that people haven't tested in a while.
Cobalt (based on squeak) or OpenQwaq if you want to have a robust 3D mutli-user distributed 3D world available.
Scratch if you want to have a kids-ready programming environment out of the box.
All of these are based off squeak.
You have several flavors of VM available with each of the above. Cog and CogMT are designed to be accelerated VMs that use a just in time compiler for extra speed.
There are also experimental GUIs, such as Cuis and there's a standalone VM called "SqueakNOS" to be used in place of a host OS such as Mac OS or Linux.
In a few months, there should be a massively scalable multi-core system available called SiliconSqueak that implements the Squeak VM in hardware.
I've no doubt missed a few things. Squeak is a research tool for many people in the computer world and some implement commercial products using it.