Even if you give a fully qualified path to CDLL or cdll.LoadLibrary(), you may still need to set LD_LIBRARY_PATH before invoking Python. If the shared library you load explicitly refers to another shared library and no "rpath" is set in the .so for that library, then it won't be found, even if it has already been loaded. An rpath in a library specifies a search path to be used to search for other libraries needed by that library
For example, I have a case of a set of interdependent third-party libraries not produced by me. b.so references a.so. Even if I load a.so in advance:
ctypes.cdll.LoadLibrary('/abs/path/to/a.so')
ctypes.cdll.LoadLibrary('/abs/path/to/b.so')
I get an error on the second load, because b.so refers to simply 'a.so', without an rpath, and so b.so doesn't know that's the correct a.so. So I have to set LD_LIBRARY_PATH in advance to include '/abs/path/to'.
To avoid having to set LD_LIBRARY_PATH, you modify the rpath entry in the .so files. On Linux, there are two utilities I found that do this: chrpath, and patchelf. chrpath is available from the Ubuntu repositories. It cannot change rpath on .so's that never had one. patchelf is more flexible.
patchelf --set-rpath ./ somelib.so
did the trick in fixing somelib.so that loads anotherlib.so that resides in the same path. – Heinz